When zooming the screen (zooming the document instead of zooming the camera in the 3D layer), it is recommended to zoom in stages using the keyboard instead of stepless zoom by dragging. If it is a stepless zoom, it will lag gutterly.
Since I do not make a living drawing and do not have the opportunity to draw pictures in CLIP STUDIO now, I do not have the knowledge of manuscript settings and export settings that professionals and amateurs should know. Please note that it is set only to create the original image for this "explanation".

This is a model with a heavy rendering load, especially when the transparent material object is visible. Don't forget to save your manuscript before rendering.
Model production and rendering work environment on CLIP STUDIO is PC purchased 4~5 years ago Processor: Intel(R) Core(TM) i7-4790 CPU @ 3.60GHz 3.60 GHz, Installed RAM: 32.0 GB
With this spec, even if it does not freeze at the time of rendering, it will be "in a quiet state" for a while. After that, the rendering process begins, but sometimes if you don't click the screen once, you may be in bed.
If you don't like the rendering result and try again, delete the folder of the failed work instead of Ctrl + Z, turn off the "extract line" of the properties of the 3D layer that is in the hidden waiting state, and then display it and resume rendering. If you move from hide to show while "extract line" is ON, there is a risk of semi-freezing.

The original manuscript size before reduction is A4 (600 dpi). After rendering, the main line (vector) is narrowed by filtering, and the tone layer is changed to a gray display. Changed the tone layer other than the one at the bottom of the tone layer to multiply.
We do not process the lines by hand using pen tools or erasers at all. I don't use textures or normal maps.

Line art (only the two line art layers created after rendering are set to monochrome)

Line art (both monochrome and grayed out)

Alchemy Set A High includes an opaque material version of the object using transparent material and a version with an increased number of vertices in the skeleton book. In order to lighten the initial loading load, the transparent version object and the vertex increase version of the skeleton book are hidden by default.
Alchemy Set A Low has removed the version with transparent materials and the vertex increase version of the skeleton book.
Rendering time example: Opaque object and 1 minute and 10 seconds when using the normal version of the skeleton book. 2 minutes and 40 seconds when using a skeleton book with a transparent object and an increased number of vertices in the same composition.
If you use transparent materials, they will be extremely heavy.

Please add the flame of the alcohol lamp by yourself.

Skeleton book (normal version)

Skeleton book (vertex increase version)

This mushroom and skeleton book have been checked in "Google Lens" to see if "something that is very similar at a bad level" already exists.
If you are considering purchasing, you can see this model from all directions on Sketchfab, which can be reached from my profile link, so please double-check the lens yourself.
This is a precautionary request to avoid risk, not an invitation to "like" on Sketchfab or see my other models.
In addition, if a user who purchased it reports that "there was already something that was very similar at a bad level", and we decide that it is better to change it here as well, it will take some time, but we will recreate it and replace it.