This is the workspace I use for everything but it's perfect for webtoons and animating. It really drives up efficiency.
Note: I think it'd work best on a larger screen tablet, though it takes up less screen space than the default workspace.

I took some inspiration from animation programs for this.
I'm not sure if the command bar settings come with this material but you just need to right-click and add horizontal flip, vertical flip, rotate right, rotate left, and reset rotation in case it doesn't.
Other key features:
-The sizes are easily accessible if you're right handed, it makes changing the pen size a lot quicker. (Move it to the other side if you're a lefty)
- It's much faster to pick colors if you have your palettes, your wheel, and your color history in the same place. It's amazing for animation and for comics.
- Moving objects and tranforming them being close together also adds to efficiency.
- Everything I use a lot is on the left, and everything I need to have easily referenced is on the right (I tend to have my layers open all the time, so having anything else I use a lot on that side would be bad)
It took me a while to build this workspace, small changes over a long time. Hopefully you'll notice an increase in efficiency too!