Workspace
color history and Layer properly on the left collapsed, everything else you need on the right side so its easy to acces if you're right handed.
Only looks good on 2560 x 1440
(in other words, QHD resolution)
Example on a QHD screen:
Example on a 1920 x 1080 screen: (you will need to adjust the Sub tool palette + color set + brush size and the tool properties for it to fit better, but you can also just remove the tool properties or hide them within the brush palette if you're ok with that)