This is by no means an expert animation layer setup, but it's usually what I start with and it provides me with a decent foundation for most of my character animation.
Setup with guides (bounding boxes for the output and overflow frame)
Along with a few folders.

Pretty basic but its good groundwork for something more.
I use this layer template to create the animations for Unseen.
(4K size version will be available soon as well)
CANVAS SIZE OF 3315 x 1895